Protein Molecular Weight Markers
ABclonal Technology DDX51 Rabbit pAb
Enables RNA binding activity. Predicted to be involved in rRNA processing. Located in membrane.
ABclonal Technology LSM12 Rabbit pAb
Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein (PubMed34362892). Confers NAADP sensitivity to the two pore channel complex (TPCs) by acting as TPC accessory protein necessary for NAADP-evoked Ca(2+) release (PubMed34362892). ( LSM12_HUMAN,Q3MHD2 )
ABclonal Technology TXNDC12 Rabbit pAb
This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants.
ABclonal Technology SERPINI1 Rabbit pAb
This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.
ABclonal Technology NOTCH2 Rabbit pAb
This gene encodes a member of the Notch family, a group of Type 1 transmembrane proteins with an extracellular domain containing multiple epidermal growth factor-like (EGF) repeats and an intracellular domain with diverse domains. Notch family proteins regulate developmental processes by controlling cell fate decisions through an evolutionarily conserved intercellular signaling pathway. In Drosophila, Notch interacts with ligands (delta, serrate) to regulate development, and similar ligands have been identified in humans, though their interactions with human Notch proteins are not fully understood. This protein is cleaved in the trans-Golgi network and presented as a heterodimer on the cell surface, acting as a receptor for membrane-bound ligands. It may be involved in vascular, renal, and hepatic development. Two transcript variants encoding different isoforms have been identified.
ABclonal Technology TCTA Rabbit pAb
Involved in negative regulation of osteoclast differentiation and osteoclast fusion. Predicted to be integral component of membrane.
ABclonal Technology GALK1 Rabbit pAb
Galactokinase is a major enzyme for the metabolism of galactose and its deficiency causes congenital cataracts during infancy and presenile cataracts in the adult population.
ABclonal Technology SNW1 Rabbit pAb
This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants.
ABclonal Technology Ran Rabbit pAb
RAN (ras-related nuclear protein) is a small GTP-binding protein in the RAS superfamily, essential for RNA and protein translocation through the nuclear pore complex. It also regulates DNA synthesis and cell cycle progression. RANs nuclear localization requires regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Besides its role in nuclear-cytosol exchange, RAN also influences microtubule network formation and organization, particularly during mitosis. RCC1 generates a high concentration of RAN-GTP near chromatin, promoting microtubule nucleation. RAN is an androgen receptor (AR) coactivator and interacts differently with polyglutamine in AR. Expansion of polyglutamine repeats in AR is linked to Kennedys disease (spinal and bulbar muscular atrophy), where weak coactivation may lead to partial androgen insensitivity.
ABclonal Technology ATP6V1G3 Rabbit pAb
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits a, c, c, c and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three G subunit proteins. Transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology FBXO21 Rabbit pAb
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.
ABclonal Technology ALDH16A1 Rabbit mAb
This gene encodes a member of the aldehyde dehydrogenase superfamily. The family members act on aldehyde substrates and use nicotinamide adenine dinucleotide phosphate (NADP) as a cofactor. This gene is conserved in chimpanzee, dog, cow, mouse, rat, and zebrafish. The protein encoded by this gene interacts with maspardin, a protein that when truncated is responsible for Mast syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology PSMD14 Rabbit pAb
This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2.
S2 Media 15x100mm Chameleon™ COLOREX™ KPC (RUO), 10/pack
Chameleon™ COLOREX™ KPC (RUO) is a selective and differential, chromogenic culture medium used for the qualitative direct detection of gastrointestinal colonization with Carbapenem-Resistant Enterobacteria (CRE). Test specimens include rectal swabs and stools. For Research Use Only (RUO). Not for use in diagnostic procedures unless Laboratory Developed Test (LDT) validation with the product has been completed. Further identification, susceptibility testing, and epidemiological typing should be performed on suspect colonies.• Product meets CLSI performance criteria.• Chameleon™ COLOREX™ KPC should be used by trained professionals within a laboratory setting. • For in vitro diagnostic (IVD) use.• Product is not intended for use in the diagnosis or treatment of disease or other human conditions.